Pharmacognostic Review on Kurdish Plant Pterocephalus nestorianus

  • Faiq Hama Saeed Hussain TIU-Research Center, Tishk International University, Erbil, Kurdistan Region, Iraq
  • Mehmet Ozdemir Faculty of Dentistry, Tishk International University, Erbil, Kurdistan Region, Iraq
  • Javed Ahamad Faculty of Pharmacy, Tishk International University, Erbil, Kurdistan Region, Iraq
  • Fuad O. Abdullah Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq
Keywords: Pterocephalus nestorianus, Caprifoliaceae, Lawa, Phytochemistry, Pharmacology.


The genus Pterocephalus, one of the most important genera of Caprifoliaceae family, comprises about 30 species which are usually found in sunny, dry, rocky crevices, mostly in Europe and Western Asia. Nine species are native to the Kurdistan region of Iraq. Pterocephalus nestorianus Nab. is an important plant of this genera and locally known as Lawa. It is widely used in folkloric medicines in Kurdistan for treating inflammation and oral diseases. It is also widely used as ornamental plant and component of many herbal formulations, all around the world. The aim of the present study is to collect authentic literature on classification, geographic distribution, eco-cultural health, traditional uses, phytochemistry, biological (environmental) activities and pharmacological properties of P. nestorianus.



Abdullah F.O., Hussain F.H.S., Sardar A.S., Vita-Finzi P., Vidari G. 2016. Phytochemistry and Ethnopharmacology of Medicinal Plants Used on Safeen Mountain in the Kurdistan Region of Iraq. Nat Prod Commun. 11(12): ttps://
ABDUL D.A. & HUSSAIN F.H.S. 2018. Synthesis of some new betti bases via one-pot three-component reaction of β-naphthol, primary diamine and substituted aromatic aldehydes. Znco J. Pure Applied Sci. 30(1): 56-64.
Abdullah F.O., Hussain F.H.S., MANNUCCI B., CUCCAD L., VIDARI G. 2018. Phytochemical investigation and antioxidant effects of different solvent extracts of Pterocephalus nestorianus Nab., growing in Kurdistan Region-Iraq. Sceince J. Uni. Zakho. 6(1): 21-25.
ABDULLAH F.O., HUSSAIN F.H.S., MANNUCCI B., LAPPANO R., TOSI S., MAGGIOLINI M., VIDARI, G. 2017. Composition, antifungal and antiproliferative activities of the hydrodistilled oils from leaves and flower heads of Pterocephalus nestorianus Nabelek. Chem. Biodivers. 14(7): doi: 10.1002/cbdv.201700009.
AHAMAD J., ALI M., MIR S.R. 2014. Isoflavone glycosides from aerial parts of Artemisia absinthium Linn. Chem. Natural Comp. 49(6): 696-700.
AHAMAD J., ALI M., MIR S.R. 2013. New Glycoside Esters from the Aerial Parts of Artemisia absinthium Linn. The Natural Products J. 3(4): 260-267.
AHAMAD J., ALI M., MIR S.R. 2014. New isoquinoline alkaloids from the stem bark of Berberis aristata. Indian J. Chem-B, 53:1237-1241.
AHAMAD J., AMIN S., MIR S.R. 2015. Optimization of ultrasound-assisted extraction of charantin from Momordica charantia fruits using response surface methodology, J Pharm Bioallied Sci. 7(4): 304-307.
AHMADIANI A., FEREIDONI M., SEMNANIAN S., KAMALINEJAD M., SAREMI S. 1998. Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats. J. Ethnopharmacol. 61: 229-235.
AKHGAR M. & SAFAVINIA L. 2016. Essential oil composition of Pterocephalus gedrosiacus. Chem. Nat. Compd. 52: 514-515
ALSAMARKANDI N. 1985. Principles of drugs composition (Esool Tarkeeb Aladwaii), investigated by Neglai Fathi. University of Baghdad Publication (Center for the Revival of Arab Scientific Heritage), Baghdad, p.23-46.
CRAGG G. & NEWMAN D. 2013. Natural products: a continuing source of novel drug leads. Biochim Biophys Acta, p. 3670-95.
Damtoft S., FRANZYK H., JENSE, S. 1995. Biosynthesis of secoiridoids in fontanesia. Phytochemistry. 38: 615.
FAHEM A., & ABDELAATY A. 2006. Flavanoid C-glycosides from Pterocephalus sanctus growing in Egypt. Natural Product Communication. 1: 457-459.
Fahem A., Maha M., Ahmed A., ADEL K. 2008. Anti-hepatotoxic effect of Pterocephalus sanctus growing in Egypt. J The Arab Society for Medical Research. 3: 83-87
GRAIKOU K., ALIGIANNIS N., CHINOU I. 2006. Chemical constituents from Pterocephalus perennis subsp. Perennis (Dipsacaceae). Biochemical Systematics and Ecology, 34: 438.
HARBORNE J. 1998. Phytochemical methods a guide to modern techniques of plant analysis. 3rd ed, Springer, p.107
HASSLER M. 2016. World Plants: Synonymic checklists of the vascular plants of the world (version May 2016) In: Species 2000 & ITIS Catalogue of Life, 28th September.
HOOSHANG V., MALIHA N., JALIL L., MAJID H. 2011.Volatile constituents and antimicrobial activities of Pterocephalus canus. J. Medicinal Plants Research. 5: 5646-5648
JUN T., FENG E.W., MING-HUA Q., RUI-LIN N. 1993. Triterpenoid saponins from Pterocephalus Hooker. Phytochemistry. 32: 1535-1538.
SHEKHA K.A. 2007. Systematic Study of the Genus Pterocephalus Vaill ex Adans (Dipsacaceae) in Kurdistan of Iraq’, M.Sc. thesis, Salahaddin University at Erbil, Iraq.
TOSHIAKI U. 2003. Diversity in lignan biosynthesis. Phytochemistry Rev. 2: 371-390.
Verlaque R. 1984. A biosystematic and phylogenetic study of the Dipsacaceae. In: Grant, W. (Ed.), Plant biosystematics. Academic Press, Toronto, p.307-320.
WU Y., YIN Y., LI Y., GUO F., ZHU G. 2014. Secoiridoid/iridoid subtype bis-iridoids from Pterocephalus hookeri. Magnetic Resonance in Chem. 52: 734.
WU Y.C., YING Y.J., GUO F.J., ZHU G.F. 2014. Bis-iridoid and lignans from traditional Tibetan herb Pterocephalus hookeri. Biochemical Systematics and Ecology. 56: 209-212.
YANG P., LI Y., LIU X., JIANG S. 2007. Determination of free isomeric oleanolic acid and ursolic acid in Pterocephalus hookeri by capillary zone electrophoresis. J Pharm Biomedical Anal. 43: 1331-1334.
ZHANG L., HU J.J., LIN J.W., DU G.H. 2009. Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B. Clarke) Hoeck, J. Ethnopharmacol. 123: 510-5
How to Cite
Hussain, F., M. Ozdemir, J. Ahamad, and F. O. Abdullah. “Pharmacognostic Review on Kurdish Plant Pterocephalus Nestorianus”. ZANCO Journal of Pure and Applied Sciences, Vol. 31, no. 5, Oct. 2019, pp. 53-60, doi:10.21271/zjpas.31.5.7.
Biology and Medical Researches