Synthesis, Spectroscopic study and Biological activity of some New Heterocyclic compounds derived from Sulfadiazine

  • Sangar A. Hassan Department of Chemistry, College of Science, University of Raparin, Sulaimanyah, Kurdistan Region, Iraq
  • Media Noori Abdullah Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq
Keywords: Sulfadiazine, β-lactam, Pyrrolone, Antioxidant, Antibacterial

Abstract

This study illustrates the synthesis and spectroscopic study of new β-lactam and novel Pyrrolone derivatives with the study of their antioxidant and antibacterial activities. This study included two major steps, the first step involved the synthesis of imine derivatives (3a-j) from sulfadiazine. The second step contained the synthesis of 2-Azetidinone (4a-j) and Pyrrolone (5a-j) heterocyclic compounds that have been generated through the reaction between synthesized imine derivatives with chloroacetyl chloride and fumaryl chloride in the presence of triethylamine, respectively. The structures of the synthesized compounds were confirmed on the basis of their spectral data such as FT-IR, 1H-NMR and 13C-NMR spectra, which provided the expected frequencies and signals. Lastly, all products were screened for the antioxidant activity and against two kinds of bacteria Staphylococcus aureus G (+ve) and Escherichia coli G (-ve) microorganisms. The products showed lower to high antioxidant activity as compared to standard ascorbic acid. Some of the products evaluated inactive and others slight to high activity against both kinds of bacteria.

Author Biography

Media Noori Abdullah, Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq

Science \ Chemistry

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Published
2019-12-05
How to Cite
A. Hassan, S. and Abdullah, M. (2019) “Synthesis, Spectroscopic study and Biological activity of some New Heterocyclic compounds derived from Sulfadiazine”, Zanco Journal of Pure and Applied Sciences, 31(6), pp. 92-109. doi: 10.21271/zjpas.31.6.10.
Section
Biology and Medical Researches