Effect of Vitamen E on Monosodium glutamate in some biochemical and Immunity parameters in Rats

  • Mohammed J. Mohammed Department of Food Science, College of Agriculture, Tikrit University, Tikrit, IRAQ.
  • Abd Al- Rahman M. Khalil Department of Food Science, College of Agriculture, Tikrit University, Tikrit, IRAQ.
Keywords: Monsodium glutamate, Vit. E, biochemical and immunity parameters


The purpose of this study was to investigate the role of vitamin E in reducing the effect of monosodium glutamate in some biochemical and immunological variables in adult male rats for 28 days. The results showed a significant decrease in (P <0.05) in the efficacy of all enzymes measured for vitamin E groups compared with groups of animals that were dosage with monosodium glutamate alone. This study showed a significant decrease in the values of creatinine and urea when added vitamin E with MSG compared with the groups of animals added the monosodium glutamate alone. The results of the study showed a significant increase in in immunoglobulin IgM and IgA for groups treated with vitamin E and MSG compared with the values of the groups of animals that were dosage with monosodium glutamate alone.


Abdel-Reheim, E. S., Abdel-Hafeez, H. A., Mahmoud, B.M., Abd-Allah, E. N. (2014). Effect of food additives (monosodium glutamate and sodium nitrite) on some biochemical parameters in albino rats. Int. J. Bioassays. 3(8): 3260-3273.
Adekomi D. A.,(2010) “Madagascar Periwinkle (Catharanthusroseus) Enhances Kidney and Liver Functions in WistarRats,” International Journal of Biomedical and Health
Sciences, 6 (4) : 245-254.
Anwar. M. M and Mohamed. N. E.(2010) Impact of Flax Seed and Canola Oils Mixture Supplementation on The Physiological and Biochemical Changes Induced by Monosodium Glutamate in Rats. Journal of Radiation Research and Applied Sciences. J. Rad. Res. Appl. Sci., Vol. 3, No 3(B), p. 943 - 964
Atessahin A.; S. Yilmaz; I. Karahan; I. Pirincci and B. Tasdemir,( 2005) “The Effects of Vitamin E and Selenium on Cypermethrin-Induced Oxidative Stress in Rats,” Türkish Journal of Veterinary and Animal Sciences, 29(2) : 385-391.
Ateya R. H.; Nabil M. T.; Abd Elwahab A. M.; Mohammed A. L. and ElMorshedy A. M.(2016) Effect of Monosodium Glutamate and Sodium Nitrite on Some Biochemical Parameters in Japanese Quails. Alexandria Journal of Veterinary Sciences 48 (1): 107-114.
Attia A. M.; Omnia G. R.; Maha H. M.; El-Haggar E. F. and El-Shobaki F. A.(2016) The Use of Spices to Protect Against Health Hazards due to Monosodium Glutamate Consumption. RJPBCS 7(6) : 2184-2192
Avanzo J. L.; C. X. De Mendonca J.; S. M. Pugine and M. De Cerqueira Cesar,( 2001) “Effect of Vitamin E and Selenium on Resistance to Oxidative Stress in Chicken Superficial Pectoralis Muscle,” Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 129(2):163-173.
Bergen H. T.; T. M. Mizuno and J. Taylor,(1998) “Hyperphagiaand Weight Gain after Gold-Thioglucose and Monosodium Glutamate: Relation to Hypothalamic Neuropeptide,” Endocrinology, 139 ( 11) : 4483-4488.
Burtis C. and E. Ashwood,( 1999) “Tietz Textbook of Clinical Chemistry,” W. B. Saunders Company, London,.
Duncan D.(1955) Multiple range and Multiple F-Test.Biometrics.11 : 1 - 42.
El-Khayat Z.; Ahmed R. E.; Mahmoud S. A, Wafaa, I. R. and Tahany, R. E. (2009). Potential effects of bee honey and propolis against the toxicity of ochratoxin A in rats. Maced. J. Med. Sci. 2(4): 311-318.
Eman G. E. H.; Rasha A. A. E. and Mariam. S. E. (2017). Assessment of the Physiological Changes Induced by Sodium Nitrite, Annatto or Mono Sodium Glutamate in Male Albino Rats. The Egyptian Journal of Hospital Medicine 67(1). Page 330 - 335.
Etim, O. E.; Farombi, E. O.;Usoh, I. F. and Akpan, E. J. (2006). The protective effect of aloevera juice on lindane induced hepatotoxcity and genotoxicity J. Pharmaceut. Sci. 19:337-340.
Eweka A. O.,(2007) “Histological Studies of the Effects of Monosodium Glutamate on the Kidney of Adult Wistar Rats,” The Internet Journal of Health, 6 (2).
Farombi, E. O. and O. O. Onyema, (2006) “Monosodium Glutamate-Induced Oxida- tive Damage and Genotoxicity in the Rat: Modulatory Role of Vitamin C, Vitamin E and Quercetin,” Human & Experimental Toxicology, 25(5) : 251- 259.
FDA, “Food and Drug Administration Background for Monosodium Glutamate,” 1995.
Hamza R. Z. and AL-Harbi M. S.,(2014) Toxicology Reports, 1: 1037-1045.
Leung A. and S. Foster,( 1996) “Encyclopedia of Common Na- tural Ingredient Used in Food,” Drugs and Cosmetics, New York, Wiley, 373-375.
Lieske. J .C.; Goldfarb, D.S. De Simone, C.and Regnier, C. (2005) Use of a probiotic to decrease enteric hyperoxaluria. Kidney Int 68:1244.
Oforofuo I. A. O.; J. U. E. Onakewhor and P. E. Idaewor,(1997) “The Effect of Chronic Administration of MSG on the Histology of the Adult Wistar Rat Testes,” Bioscience Research Communications, 9(2).
Onakewhor J. U. E.; I. A. O. Oforofuo and S. P. Singh,(1998) “Chronic Administration of Monosodium Glutamate Induces Oligozoospermia and Glycogen Accumulation in Wistar Rat Testes,” Africa Journal of Reproductive Health, 2(2) : 190-197.
Onyema O. O.; Ebenezer O. F.; Godwin O. E.; Agwu I. U. and Godffrey O. O. (2006) Effect of Vitamin E on monosodium glutamate induced hepatotoxicity and oxidative stress in rats. Indian J. of Biochemistry and Biophysics. 43(1): 20-24.
Poli G.; E. Albano and M. U. Dianzani,(1990) “Lipid Peroxi- dation and Covalent Binding in the Early Function Impairment of Golgi Apparatus by Carbon Tetrachloride,” 8(1) : 1-10.
Rogers P. P. and Blundell J. E. (1990). Umani and appetite: Effects of monosodium glutamate on hunger and food intake in human subjects. Phsiol. Behav. 486:801-804.
Sadia. M.; Mazhar H. M. and Shemaila S. (2012). effect of ascorbic acid and alpha tocopherol on immune status of male Sprague dawley rats exposed to chronic restraint stress. J ayub med coll Abbottabad. 24 (3 - 4).
Samuels A. ( 1999) “The Toxicity/Safety of MSG: A Study in Suppression of Information,” Accountability in Research, 6(4) : 259-310.
SAS . (2001). SAS User’s guide: Statistical system, Inc. Cary, NC. USA.
Shivasharan B. D.; Nagakannan P.; Thippeswamy B. S. and Veerapur V. P.( 2013) Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats. Indian J Clin Biochem.28(3):292–8.
Tawfik, M., Al-Badr, N. 2012. Adverse Effects of Monosodium Glutamate on Liver and Kidney Functions in Adult Rats and Potential Protective Effect of Vitamins C and E. Food. Nutr. Sci. 3 (5): 651-659.
Tietz N. W., “Fundmental of Clinical Chimestry,” WB Saunder Co., Philadelphia, 1986, p. 723.
Tietz Y. (2005) Clinical Biochemistry, 6 th ed., McGraw-Hill, New York , 825
Tietz, N. W. (1999). Textbook of clinical chemistry. ed. C.A.Burtis E.R. Ashwood, W.B.Saunders.: 819 - 861,1245 - 1250.
Tokura S.; Tamura H. and Azuma I. (1999): Immunological aspects of chitin and chitin derivatives administered to animals. EXS, 87:279 – 292.
Vinodini N. A.; A. K. Nayanatara; C. Ramaswamy; V. R. Anu; D. K. Rekha; G. K. M. Damadara; B. Ahamed and R. B. Shabarinath,(2010) “Study on Evaluation of Monosodium Glutamate Induced Oxidative Damage on Renal Tissue on Adult Wistar Rats,” Journal of Chinese Clinical Medicine, 5(3) : 144-147.
How to Cite
Mohammed, M. J. and M. Khalil, A. A.- R. (2019) “Effect of Vitamen E on Monosodium glutamate in some biochemical and Immunity parameters in Rats”, Zanco Journal of Pure and Applied Sciences, 31(s4), pp. 121-125. doi: 10.21271/zjpas.31.s4.19.