The Correlation between Luteinizing hormone, Follicle stimulating hormone, Testosterone, and Prolactin Level at Different Depression Level in Polycystic Ovary Syndrome Patients
Polycystic ovary syndrome is an endocrine disorder in which the number of cysts in women’s ovaries is dramatically increased. It is a principle factor behind different symptoms and problems. Although non-life threatening, it may lead to some disease processes in later life. This study aimed to examine the alterations of luteinizing hormone, follicle stimulating hormone, testosterone and prolactin levels with increased levels of depression in polycystic ovarian syndrome (PCOS) patients. Psychological assessment of 50 women of reproductive age was performed using Beck’s Depression Inventory. In PCOS patients, depression induced LH and prolactin levels and markedly lowered FSH with a maintenance of an expected normal LH/FSH ratio. No change in testosterone was noted. Few symptoms of hirsutism were seen.
Conclusion: It seems that LH level is clearly increased and FSH level decreased significantly in comparison with their normal ranges. Prolactin tests were markedly elevated, while no alteration was noted for testosterone.
Brothers, K. J. (2010) . Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor (IR). Cell Metabolism. 12 (3): 295–305.
Lynch C.D., Sundaram R., Maisog J.M., Sweeney A.M., and Buck Louis G.M. (2014). "Preconception stress increases the risk of infertility: results from a couple-based prospective cohort study - the LIFE study."Hum. Reprot. deu 032v1-deu032.
Deeks A. A. , Gibson-Helm M. E. , Paul E. and Teede H. J. (2011). Is having polycystic syndrome predictor of poor psychological function including anxiety and depression? Human Reproduction. 26 (6):1399 – 1407.
Diamanti-Kandarakis E; Kandarakis H, Legro RS. (August 2006). The role of genes and environment in the etiology of PCOS .Endocrine; 30 (1): 19–26.
Adail E. (2008). The relationship between clinic-biochemical characteristics and psychiatric distress in young women with polycystic ovary syndrome. Journal of international medical research. (36) : 1188.
Fauser, B. C. (2011). Contemporary genetic technologies and female reproduction (Polycystic ovary syndrome) in: The Evian Annual Reproduction (EVAR) Workshop Group 17. (60) : 829–847.
Frearson, M.; Thondan, M.; Stepto, N.; Teede, H. J. (2013). Dietary. composition in the treatment of polycystic ovary syndrome: A systematic review to inform evidence-based guidelines. Human Reproduction Update. 19 (5): 432
Gory, A.; White, D. M.; Franks, S. (August 2006). "Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment". Endocrine. 30 (1): 27–33.
Kerchner A, Lester W, Stuart SP, Dokras A. (2009). Risk of depression and other mental health disorders in women with polycystic ovary syndrome: a longitudinal study. Fertile Steril. 207 – 212.
Kuczmierzyck, AR, Hardeman, PJ. (2011). Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis". Hum. Reprod.. 93 (6): 1948–56.
Legro RS. ; Strauss JF. (September 2002). Molecular progress in infertility: polycystic ovary syndrome .Fertility and Sterility. 78 (30) : 569–576.
Qiao, J.; Feng, H. L. (2010). "Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence". Human Reproduction Update. 17 (1): 17
Raja- Khan N., Stener-Victorin E., Wu X., and Richard S. L. (2011). The physiological basis of complementary and alternative medicines for polycystic ovary syndrome. J.Physiol endocrinol Metab. (301): E1-E10.
Rasgon NL. (2003). Depression in women with polycystic ovary syndrome: clinical and biochemical correlates. J Affect Disord. 74(3):299-304.
Riedel Wim J, Tineke-Klaassen and Jeroen A.J. Schmitt. (2002). Tryptophan, mood and cognitive function. “Brain, behavior and Immunity. 16(5):81-589..
Tan S. (2009). Psychological implication of infertility in women with polycystic ovary syndrome. Human Reproduction. 23(9) : 2064- 2071.
Veltman-Verhulst SM, Boivin J, Eijkemans MJ, Fauser BJ. (2012). Emotional distress is a common risk in women with polycystic ovary syndrome: a systematic review and meta-analysis of 28 studies. Hum. Reprod. Update. 18 (6): 638–51.
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