Evaluation of Homocysteine and Some Biochemical Parameters in Patients with Coronary Atherosclerosis in Erbil Governorate
An elevated homocysteine (Hcy) level in blood causes endothelial dysfunction and damage. Individuals with higher Hcy concentration have increased risks of cardiovascular disease. Ninety individuals were taken at Hawler Cardiac Surgery Center and diagnosed by coronary angiography. Blood sample collections started in October 2014 and ended in January 2015. The present study includes 60 patients who had stenosis and 30 individuals who had no stenosis as healthy group, patient and healthy groups aged >40 years old. The results of this study show that, the mean ± S.E. levels of tHcy in patient group was 17.170 ± 0.748 μmol/L, which was located above normal range for tHcy and in healthy group was 13.780 ± 0.679 μmol/L, which was located within normal range for Hcy and the concentration of tHcy was significantly higher in patient group compared to healthy group. Also, the mean values of malodialdehyde (MDA) and blood glucose concentrations were significantly higher in patient group than healthy group. Meanwhile, vitamin B12, folic acid levels were significantly higher in healthy group but TAC level was higher and not significant in healthy group when compared to patient group. On the other hand, Tch, TG, LDL and VLDL levels were significantly higher in patient group compared to healthy group. While, HDL level was significantly higher in healthy group rather than patient group. In correlation analysis, tHcy was positively and significantly correlated with LDL (r = 0.338). As well as tHcy was positively (not significantly) correlated with MDA, CH, TG, VLDL and urea, glucose (r = 0.3072; r = 0.07717; r = 0.1063; r = 0.1063; r = 0.2612; r = 0.003459) respectively. While, tHcy was negatively correlated with vitamin B12, folic acid, TAC and HDL (r = -0.02752; r = -0.2076; r = -0.021; r = -0.1554), respectively.
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