Lipid profile, oxidative stress and homocysteine in CRF patients pre- and post-hemodialysis in Erbil city
Patients with chronic renal failure CRF suffer from lipid abnormalities, changes in the level of oxidative stress status, and hyperhomocysteine, and these accelerate the development of atherosclerosis. The aim of the present study to evaluate the alteration of the serum lipid profile, oxidative stress status and plasma total homocysteine t-Hcy in CRF patients pre- and post-hemodialysis. The study included 80 patients, 36 women (45%) and 44 men (55%) in end stage renal disease ESRD patients requiring maintenance hemodialysis, and 40 subjects as control group. There is a significant increase in serum total cholesterol and triglycerides in CRF patients pre-dialysis compared as control subjects. They were decreased after hemodialysis. There is a significant decrease in the levels of high density lipoprotein-cholesterol HDL-C in CRF patients pre- and post-hemodialysis when compared to control subjects. The levels of low density lipoprotein-cholesterol LDL-C and very low density lipoprotein-cholesterol VLDL-C were significantly increased before hemodialysis compared to controls, they were decreased after hemodialysis but not significantly. Serum malondialdehyde MDA was significantly increased in CRF patients pre- and post-hemodialysis compared to controls. Total antioxidant capacity TAC levels were significantly decreased in CRF patients pre- and post-hemodialysis compared to controls. The total homocysteine t-Hcy was significantly increased in CRF patients pre- and post-hemodialysis compared to controls, they were decreased after hemodialysis.
Copyright (c) 2017 ZANCO Journal of Pure and Applied Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
ZANCO Journal of Pure and Applied Sciences (print version: ISSN 2218-0230 online version: ISSN 2412-3986, DOI: 10.21271) is published by Salahaddin University-Erbil / Department of Scientific Publications. Responsibility for the contents rests upon the authors and not upon Salahaddin University-Erbil or the Journal Editorial and Advisory Boards.
Department of Scientific Publication Office: The Central Library of Salahaddin University-Erbil, Kirkuk Road, Erbil, Kurdistan, Iraq. Cell Phone: +964 (0)750 7761675, email: firstname.lastname@example.org. www.su.edu.krd, www.zancojournals.su.edu.krd
Copyright and Reprint Permission: It is the policy of ZANCO to own the copyright to the technical contributions it publishes and to facilitate the appropriate reuse of this material by others. Photocopying is permitted with credit to the source for individuals for individual use.
Copyright © 2017. All Rights Reserved. Salahaddin University-Erbil