Histological and Biochemical effects of 1,1,1-Trichloroethane on the testes of rats

  • Naz Shwan Rashed Department of animal husbandry, College of agricultre, Salahaddin University, Erbil, Kurdistan Region, Iraq.
  • Shang Ziyad Abdulqadir Department of Biology, College of Science, Salahaddin University, Erbil, Kurdistan Region, Iraq.
  • Ahmed Hasan Ahmed Department of Dentistry, College of Dentistry, Hawler Medical University, Erbil, Kurdistan Region, Iraq.

Abstract

        The present investigation was designed to study the effect of the environmental pollutant 1,1,1, trichloroethane (TCE) on the testes of rats and the mechanism of germinal epithelial layers cell death. Two doses of this pollutant (0.4 and 2 g/kg B.W) were orally administrated to the males Wistar rats for 4 weeks. The biochemical tests have shown a significant increase (p≤0.05) in tissue malondialdehyde (MDA) level and significant decrease (p≤0.05) in serum testosterone level after exposure to TCE. The histological study showed atrophy of the germinal epithelium and appearance of the multinucleated cells in the higher dose. From these findings it can be concluded that this pollutant is toxic and cause infertility  due to decline in the level of testosterone hormone and oxidative stress production.
Published
Jun 12, 2018
How to Cite
RASHED, Naz Shwan; ABDULQADIR, Shang Ziyad; AHMED, Ahmed Hasan. Histological and Biochemical effects of 1,1,1-Trichloroethane on the testes of rats. ZANCO Journal of Pure and Applied Sciences, [S.l.], v. 30, n. 3, p. 10-19, june 2018. ISSN 2412-3986. Available at: <http://zancojournals.su.edu.krd/index.php?journal=JPAS&page=article&op=view&path%5B%5D=1997>. Date accessed: 25 june 2018. doi: http://dx.doi.org/10.21271/zjpas.30.3.2.
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Articles