Effect of occupational exposure to chemicals on some biochemical parameters

Main Article Content

musher Ismael Salih
Vyan A. Qader
Hawar J. Sadiq Hawezy

Keywords

occupational exposure Biochemical parameters Liver parameters Heavy metal

Abstract

Chemical and biological hazards may have serious implications on the exposed individuals and a wealth of quality-ensured guidance and information for health care workers is available on the internet. Harmful chemicals can get into the body if you breathe, eat, or drink them or if they are absorbed through the skin. Study group was 20-person Exposure to Occupational Chemicals in chemistry department at Koya university for more than 5 years. In addition, the study includes 20 subject as control group in this study. The blood was drawn into test tubes to estimation of lipid profile, liver parameters, kidney function tests and heavy metal. Full automatic chemical analyzer (Cobas C311) was used to determine the biochemical parameters and atomic absorption was used to estimate the heavy metals. The results showed significant decrease in ALT, AST, albumin and triglyceride, and non-significant difference in total protein, total bilirubin, cholesterol, urea, creatinine, uric acid, Hg and Pb in case group as compared to control group.

Abstract 76 | PDF Downloads 58

References

Abdel Aziz, I.I., Al Agha, S.Z. and Shehwan, O.A., 2006. Hematological and Biochemical Studies for Gasoline Toxicity among Gasoline Workers in Gaza Strip. Al-Aqsa Univ. J., 10 (SE), 41-55.
Abou-ElWafa, H.S., Albadry, A.A., El-Gilany, A.H. and Bazeed, F.B., 2015. Some biochemical and hematological parameters among petrol station attendants: a comparative study. BioMed research international 2015, 1-6.
Onyeneke, E.C. and Omokaro, E.U., 2016. Effect of occupational exposure to lead on liver function parameters. Int. J. Pharm. Med. Sci, 6, pp.15-19.
Ali Khan, A., Sultan, R., Zamani, GY. and Rahman, S.U., 2013. Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making. Journal of Biology and Life Science, 4(2), pp.116-28.
Bartemaeus, E.S. and M.J. Jacobs, 2002. The effect of exposure to petroleum products on some renal function parameter of motor mechanics in Port- Harcourt metropolis in Nigeria. Global Journal of Pure and Applied Sciences, 9(1): 1-7.
Cox, T., Griffiths, A., & Rial-González, E. (2000). Research on work-related stress: European Agency for Safety and Health at Work. Luxembourg: Office for Official Publications of the European Communities.
Dere, E., Gyborova, S., & Aydin, H. (2003). The effect of benzene on serum hormones and the activity of some enzymes in different tissues of rats. Acta Veterinaria (Beograd), 53(2-3), 87-101.
Enuneku, A.A., 2010. Toxicological and biochemical alterations in adult amphibians (Hoplobatrachus occipitalis and Bufo maculates) exposed to cadmium and lead. Ph.D Thesis, University of Benin, Nigeria.
Fiedler, N. and Lerman, S., 2007. Organic solvents and fuels. Environmental and occupational medicine, 4th edn. Lippincott Williams & Wilkins, Philadelphia, 1102.
Goyer, R.A., 1993. Lead toxicity: current concerns. Environmental Health Perspective 100: 177-187.
Haji, A. and H. Amir, 2012. The effect of occupational exposure to lead on blood hemoglobin concentration of workers in Kermanshah oil refinery. Iranian Journal of Toxicology, 19: 766-770.
Ladou, J. and Harrison, R. (2014) Occupational and Environmental Medicine. McGraw-Hill, Philadelphia.
Malaguarnera, G., Cataudella, E., Giordano, M., Nunnari, G., Chisari, G. and Malaguarnera, M. 2012. Toxic Hepatitis in Occupational Exposure to Solvents. World Journal of Gastroenterology, 18, 2756-2766.
Melnick R. L., 1992. “An alternative hypothesis on the role of chemically induced protein droplet (α2u-globulin) nephropathy in renal carcinogenesis,” Regulatory Toxicology and Pharmacology, 16 (2), 111–125.
Paul, M.D., B. Kristal, B.J. Estella, R. Ashtanazi and J. Ribak, 1999. Lead exposure in battery factory worker is not associated with anemia. Journal of Occupational and Environmental Medicine, 41(2), 120-123.
Pfaller W. and Gstraunthaler G., 1998. “Nephrotoxicity testing in vitro: what we know and what we need to know,” Environmental Health Perspectives, 106 (2), 559–569.
Qin, W., Xu, Z., Lu, Y., Zeng, C., Zheng, C., Wang, S. and Liu, Z., 2012. Mixed organic solvents induce renal injury in rats. PloS one, 7(9), p.e45873.