Synthesis, in vitro Antimicrobial assay and Molecular Docking Studies of some new Symmetrical Bis-Schiff Bases and their 2-Azetidinones.

  • Sangar Ali Hassan Department of Chemistry, College of Science, Raparin University-Sulaymaniyah, Kurdistan Region, Iraq
  • Media Noori Abdullah Department of Chemistry, College of Science, Salahaddin University - Erbil, Kurdistan Region, Iraq
  • Dara Muhammed Aziz Department of Chemistry, College of Science, Salahaddin University - Erbil, Kurdistan Region, Iraq
Keywords: Symmetrical Schiff Base, 2-Azetidinone, Antimicrobial assay, and Molecular Docking Studies.

Abstract

Four membered cyclic amides that are a broadly utilized class of antimicrobial agents up to now. Moreover, Symmetrical Bis-Schiff bases constitute an extraordinary class of strained compounds with varied applications and building blocks for the synthesis of 2-Azetidinones antibiotics. Because of those over biological significance, this study concludes a versatile synthetic precursor for the synthesis of the new Symmetrical Bis-Schiff bases and 2-Azetidinones in an exceedingly high yield. 2-Azetidinones were synthesized through [2+2] dichloroketene-imine cycloaddition reaction. The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR, and 13C-NMR. Additionally, the products were assayed against two antibacterial types Gram-positive (S. aureus) and Gram-negative (E. coli) microorganisms and two varieties of fungal strains A. niger, T. mentagrophytes by broth microdilution method. As a result, all synthesized compounds displayed good antimicrobial activities against resistant strains. Finally, molecular docking studies were explained the inhibitory activities for the new products with the target (PDB ID: 1MWU) methicillin acyl-Penicillin binding protein 2a from methicillin-resistant Staphylococcus aureus strain 27r at 2.60 Å resolution.

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Published
2021-04-18
How to Cite
Hassan, S., Noori Abdullah, M. and Muhammed Aziz, D. (2021) “Synthesis, in vitro Antimicrobial assay and Molecular Docking Studies of some new Symmetrical Bis-Schiff Bases and their 2-Azetidinones.”, Zanco Journal of Pure and Applied Sciences, 33(2), pp. 34-50. doi: 10.21271/ZJPAS.33.2.4.
Section
Biology and Medical Researches